Triethylamine → HCID 178513338, compound

HRID 2241877Notes

Reaction equation

HRID 2241877 reaction equation
Cl.[OH:2][NH3+:3].[F:4][C:5]1[CH:10]=[CH:9][C:8]([CH:11]([OH:34])[CH2:12][CH2:13][CH:14]2[C:17](=[O:18])[N:16]([C:19]3[CH:26]=[CH:25][C:22]([C:23]#[N:24])=[CH:21][CH:20]=3)[CH:15]2[C:27]2[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=2)=[CH:7][CH:6]=1.C(N(CC)CC)C>C(O)(C)C>[F:33][C:30]1[CH:29]=[CH:28][C:27]([CH:15]2[CH:14]([CH2:13][CH2:12][CH:11]([C:8]3[CH:7]=[CH:6][C:5]([F:4])=[CH:10][CH:9]=3)[OH:34])[C:17](=[O:18])[N:16]2[C:19]2[CH:26]=[CH:25][C:22]([C:23]([NH:3][OH:2])=[NH:24])=[CH:21][CH:20]=2)=[CH:32][CH:31]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 22029257Hydroxyammonium hydrochlorideHCID 68546382HCID 68546382, compound

Product 1

HCID 178513338HCID 178513338, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

279 mg of hydroxylammonium hydrochloride were added to a solution of 280 mg of 4-[3-[3-(4-fluorophenyl)-3-hydroxypropyl]-2-(4-fluorophenyl)-4-oxoazetidin-1-yl]benzonitrile (11) and 0.65 ml of triethylamine in 15 ml of isopropanol. The mixture was stirred at room temperature for 12 h. The reaction solution was extracted twice with ethyl acetate/water. The organic phases were dried over magnesium sulfate and concentrated. This gave the product of molecular weight 451.48 (C25H23F2N3O3); MS (ESI): 452.10 (M+H+).

Workup

  1. extractionThe reaction solution was extracted twice with ethyl acetate/water
  2. dry with materialThe organic phases were dried over magnesium sulfate
  3. concentrationconcentrated
  4. customThis gave the product of molecular weight 451.48 (C25H23F2N3O3)

Sources & evidence

ORD record
ord-167b2e0da78b49e58c24fce3d4b71366
Source dataset
uspto-grants-2010_03
Patent number
US07671047B2

Reaction notes

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