反应详情

温度

50 °C

To a solution of 8-(1.4-dioxa-8-azaspiro[4.5]dec-8-yl)-7-fluoroquinoline (Step 2, 1.73 g) in tetrahydrofuran (50 mL) was added aq. 2N aqueous HCl (10 mL). The resulting mixture was stirred at 50° C. for 3 hours. The reaction mixture was then cooled to room temperature, poured into 2.5 N aqueous NaOH and extracted with ethyl acetate. The combined organic layers were dried over anhydrous MgSO4, filtered and concentrated on a rotary evaporator. The crude product was purified by flash chromatography on silica gel using hexane/ethyl acetate to give 1.17 g of the desired product as a yellow oil; MS (ES) m/z (relative intensity): 245 (M+H)+ (100).

1. temperatureThe reaction mixture was then cooled to room temperature
2. extractionextracted with ethyl acetate
3. dry with materialThe combined organic layers were dried over anhydrous MgSO4
4. filtrationfiltered
5. concentrationconcentrated on a rotary evaporator
6. customThe crude product was purified by flash chromatography on silica gel