Acetone → HCID 86610297, compound

HRID 2242011Notes

Reaction equation

[F:1][C:2]1[CH:11]=[CH:10][C:9]([N:12]2[CH2:17][CH2:16][CH:15]([N:18]3[CH2:23][CH2:22][N:21]([C:24]4[CH:25]=[C:26]([O:34][CH3:35])[CH:27]=[C:28]5[C:33]=4[N:32]=[CH:31][CH:30]=[CH:29]5)[CH2:20][CH2:19]3)[CH2:14][CH2:13]2)=[C:8]2[C:3]=1[C:4]([O:40][CH3:41])=[CH:5][C:6]([C:36]([F:39])([F:38])[F:37])=[N:7]2.C[C:43]([CH3:45])=[O:44].C1C[O:49][CH2:48][CH2:47]1.[OH2:51]>>[C:43]([OH:44])(=[O:49])[CH2:45][CH2:25][C:26]([OH:34])=[O:51].[C:43]([OH:44])(=[O:34])[CH2:45][CH2:47][C:48]([OH:49])=[O:51].[F:1][C:2]1[CH:11]=[CH:10][C:9]([N:12]2[CH2:13][CH2:14][CH:15]([N:18]3[CH2:23][CH2:22][N:21]([C:24]4[CH:25]=[C:26]([O:34][CH3:35])[CH:27]=[C:28]5[C:33]=4[N:32]=[CH:31][CH:30]=[CH:29]5)[CH2:20][CH2:19]3)[CH2:16][CH2:17]2)=[C:8]2[C:3]=1[C:4]([O:40][CH3:41])=[CH:5][C:6]([C:36]([F:37])([F:39])[F:38])=[N:7]2

Participants

Reactant 4

HCID 180Acetone

HCID 962Water

HCID 8028Tetrahydrofuran

HCID 12004141HCID 12004141, compound

Product 1

HCID 86610297HCID 86610297, compound

Procedure

The weight of the resulting product was 311 g, or about 91.6% yield. NMR analysis indicated that the compound was the disuccinate salt form of 5-fluoro-4-methoxy-8-(4-(4-(6-methoxy-quinolin-8-yl)-piperazin-1-yl)-piperidin-1-yl)-2-trifluoromethyl-quinoline. In addition, residual solvents were found at concentrations of 0.047% for acetone, 0.027% for THF, and 0.14% for water.

Sources & evidence

ORD record: ord-7c0a634077784ae3b8edb4141402a65c
Source dataset: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07671056B2

Reaction notes

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