Ammonium Hydroxide → Benzenesulfonamide, 2-methoxy-6-nitro-

HRID 2242047Notes

Reaction equation

HRID 2242047 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([N+:9]([O-:11])=[O:10])[C:4]=1[S:12](Cl)(=[O:14])=[O:13].[OH-].[NH4+:17]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([N+:9]([O-:11])=[O:10])[C:4]=1[S:12]([NH2:17])(=[O:14])=[O:13]

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 866088532-Methoxy-6-nitrobenzenesulfonyl chloride

Product 1

HCID 66915997Benzenesulfonamide, 2-methoxy-6-nitro-

Procedure

A mixture of 2-methoxy-6-nitro-benzenesulfonyl chloride (12.8 g, 50.87 mmol) and 25% ammonium hydroxide is swirled at 65° C. on a rotavap. After 15 min the volume of the resulting solution is reduced to half by evaporation of volatiles at reduced pressure. Collecting the precipitate by filtration after cooling gives 2-methoxy-6-nitro-benzenesulfonamide.

Workup

  1. customis swirled at 65° C. on a rotavap
  2. customAfter 15 min the volume of the resulting solution is reduced to half by evaporation of volatiles at reduced pressure
  3. customCollecting the precipitate
  4. filtrationby filtration
  5. temperatureafter cooling

Sources & evidence

ORD record
ord-3504e14a4e6448918d177369d62e6514
Source dataset
uspto-grants-2010_03
Patent number
US07671063B2

Reaction notes

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