Fexofenadine → Fexofenadine Hydrochloride

HRID 2242093Notes

Reaction equation

[ClH:1].CO.[CH3:4][C:5]([C:38]([OH:40])=[O:39])([C:7]1[CH:12]=[CH:11][C:10]([CH:13]([OH:37])[CH2:14][CH2:15][CH2:16][N:17]2[CH2:22][CH2:21][CH:20]([C:23]([OH:36])([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:19][CH2:18]2)=[CH:9][CH:8]=1)[CH3:6]>>[CH3:6][C:5]([C:38]([OH:40])=[O:39])([C:7]1[CH:12]=[CH:11][C:10]([CH:13]([OH:37])[CH2:14][CH2:15][CH2:16][N:17]2[CH2:18][CH2:19][CH:20]([C:23]([OH:36])([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)[C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[CH2:21][CH2:22]2)=[CH:9][CH:8]=1)[CH3:4].[ClH:1]

Participants

Reactant 2

HCID 3348Fexofenadine

HCID 21893726Hydrochloride methanol2×

Product 1

HCID 63002Fexofenadine Hydrochloride

Procedure

The diluted HCl/methanol solution was cooled (T<10° C.). Fexofendine base (50 grams) (1.88% H2O) was reacted with the diluted HCl/methanol solution, to form a fexofenadine-HCl solution. The molar ratio between fexofenadine-base and HCl was 1:1.

Sources & evidence

ORD record: ord-21c641558b9f423b91c0580f697bb11e
Source dataset: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07671071B2

Reaction notes

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