Methanesulfonic Acid → N-[amino-(4-methylpiperazin-1-yl-amino)-methylene]-4-methylbenzenesulfonamide

HRID 2242153Notes

Reaction equation

HRID 2242153 reaction equation
C[C:2]1[CH:6]=C(C)[N:4]([C:8](=[NH:20])[NH:9][S:10]([C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=2)(=[O:12])=[O:11])[N:3]=1.CS(O)(=O)=O.N[N:27]1[CH2:32]CN(C)[CH2:29][CH2:28]1>>[NH2:20][C:8]([NH:4][N:3]1[CH2:2][CH2:6][N:27]([CH3:32])[CH2:28][CH2:29]1)=[N:9][S:10]([C:13]1[CH:14]=[CH:15][C:16]([CH3:19])=[CH:17][CH:18]=1)(=[O:11])=[O:12]

Participants

4

Reactant 3

HCID 6395Methanesulfonic AcidHCID 813491-Amino-4-methylpiperazineHCID 178427489N-[(3,5-dimethylpyrazol-1-yl)-iminomethyl]-4-methylbenzene-sulfonamide

Product 1

HCID 67176487N-[amino-(4-methylpiperazin-1-yl-amino)-methylene]-4-methylbenzenesulfonamide

Procedure

The compound of Example 8 was prepared according to the accompanying synthesis procedure from 0.5 ml of N-[(3,5-dimethylpyrazol-1-yl)-iminomethyl]-4-methylbenzene-sulfonamide solution (0.2 M, acetonitrile) with 19 mg of methanesulfonic acid and 0.5 ml of N-amino-4-methylpiperazine solution (1.0 M, acetonitrile) and filed in a substance databank. Calculated mol. wt. 311.40; found mol. wt. (M+H) 312.2; 623.0 (Dimer)

Sources & evidence

ORD record
ord-b609d3a693cb4dc0841e06621dc67c6a
Source dataset
uspto-grants-2010_03
Patent number
US07671074B2

Reaction notes

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