反应详情

温度

75 °C

Triethylamine (68 mL, 498 mmol) was added to a solution of 6-chloronicotinonitrile (30.0 g, 217 mmol), hydroxylamine hydrochloride (33.0 g, 476 mmol) and ethanol (325 mL) and stirred for 12 hours at 75° C. The reaction mixture was cooled to room temperature, quenched with H2O (400 mL) and the partially concentrated in vacuo. The resulting slurry was filtered and dried to provide the title compound as a crude white solid (37.5 g).

1. temperatureThe reaction mixture was cooled to room temperature
2. customquenched with H2O (400 mL)
3. concentrationthe partially concentrated in vacuo
4. filtrationThe resulting slurry was filtered
5. customdried