Diisopropylcarbodiimide → HCID 178509448, compound

HRID 2242374Notes

Reaction equation

HRID 2242374 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]([F:23])([F:22])[F:21])[CH:14]=1)[C:7]([C:24]([OH:26])=O)=[CH:6]2)#[N:2].Cl.[NH2:28][C@H:29]1[CH2:34][CH2:33][C@H:32]([OH:35])[CH2:31][CH2:30]1.C(N=C=NC(C)C)(C)C>>[OH:35][C@H:32]1[CH2:33][CH2:34][C@H:29]([NH:28][C:24]([C:7]2[N:8]([CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]([F:21])([F:23])[F:22])[CH:14]=3)[C:9]3[C:5]([CH:6]=2)=[CH:4][C:3]([C:1]#[N:2])=[CH:11][CH:10]=3)=[O:26])[CH2:30][CH2:31]1

Participants

4

Reactant 3

HCID 12734DiisopropylcarbodiimideHCID 685431065-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acidHCID 178479278HCID 178479278, compound

Product 1

HCID 178509448HCID 178509448, compound

Procedure

The title compound was prepared using 5-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid [prepared from 3-(trifluoromethoxy)benzyl bromide and ethyl 5-cyanoindole-2-carboxylate] and trans-4-aminocyclohexanol hydrochloride in a manner similar to that described in Example 11 but using 1,3-diisopropylcarbodiimide instead of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide.

Sources & evidence

ORD record
ord-048d7b09a04b466f88196b88ac8f4a25
Source dataset
uspto-grants-2010_03
Patent number
US07671080B2

Reaction notes

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