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HRID2242426

反应详情

EQUATION

反应方程式

HRID 2242426 的结构方程式

REACTANTS

反应物

3
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：[Li+].[OH-]
HCID3939

Lithium hydroxide anhydrous

HLiO

结构：C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H](Oc2cc(-c3ccccc3)nc3cc(OC)ccc23)C[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)NC)C1CCCCC1)C(C)(C)C)C(=O)OCC
HCID59204178

未命名化合物

PRODUCTS

生成物

1
结构：C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H](Oc2cc(-c3ccccc3)nc3cc(OC)ccc23)C[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)NC)C1CCCCC1)C(C)(C)C)C(=O)O
HCID15959337

(2S)-N-[[(1R,2R,4S)-2-[[[(1R,2S)-1-Carboxy-2-ethenylcyclopropyl]amino]carbonyl]-4-[(7-methoxy-2-phenyl-4-quinolinyl)oxy]cyclopentyl]carbonyl]-3-methyl-L-valyl-2-cyclohexyl-N-methylglycinamide

C44H55N5O8

收率 67%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1.CO.O
溶剂HCID21892291

未命名化合物

PROCEDURE

实验过程

To a solution of compound 39 (20 mg, 0.025 mmol) in THF/MeOH/water 2:1:1 (2 mL) at 0° C. was added 1M LiOH (175 uL, 0.175 mmol) and the solution was allowed to attain room temperature and was stirred for 48 h. The solution was acidified to pH 3 with 1M HCl and was then evaporated and coevaporated with toluene. The crude product was purified by HPLC (MeOH/water 6:4+0.5% TFA followed by MeOH/water 4:1+0.2% TFA) to give compound 40 (13 mg, 67%) as a colorless solid.

WORKUP

后处理

  1. customto attain room temperature
  2. customwas then evaporated
  3. customThe crude product was purified by HPLC (MeOH/water 6:4+0.5% TFA followed by MeOH/water 4:1+0.2% TFA)