反应详情

To a solution of 2-tert.butoxycarbonylamino-3,3-dimethyl butyric acid (500 mg, 2.16 mmol), Amino-cyclohexyl-acetic acid methyl ester (444 mg, 2.59 mmol) and HATU (2 g, 5.40 mmol) in DMF (20 mL) was added diisopropylethylamine (1.88 mL, 10.8 mmol). The solution was stirred for 1 hrs at r.t. and diluted with dichloromethane (40 mL). This solution washed with aqueous. NaHCO3 (sat.) and water (×2), dried and concentrated. The product was >95% pure. M+H+385.4.

1. washThis solution washed with aqueous
2. dry with materialNaHCO3 (sat.) and water (×2), dried
3. concentrationconcentrated