反应详情

To a solution of tert-butylisothiocyanate (5.0 mL, 39 mmol) in CH2Cl2 (200 mL) were added isopropylamine (4.0 mL, 47 mmol) and diisopropylethylamine (DIEA) (6.8 mL, 39 mmol), and the mixture was stirred at rt for 2 h. The reaction mixture was diluted with EtOAc, washed with 10% citric acid (2×), saturated NaHCO3 (2×), H2O (2×), and brine (1×). The organic layer was dried (MgSO4) and evaporated to yield the title compound (3.3 g, 52%) as a white solid which was used without further purification.

1. washwashed with 10% citric acid (2×), saturated NaHCO3 (2×), H2O (2×), and brine (1×)
2. dry with materialThe organic layer was dried (MgSO4)
3. customevaporated