HRID2242452

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

HCID12052

Silane, triethyl-

C6H16Si

结构：C=CC1C[C@]1(NC(=O)[C@@H]1C[C@@H](Oc2cc(-c3csc(NC(C)C)n3)nc3cc(OC)ccc23)C[C@H]1C(=O)OC(C)(C)C)C(=O)OCC

HCID86614779

未命名化合物

PRODUCTS

生成物

结构：C=CC1C[C@]1(NC(=O)[C@@H]1C[C@@H](Oc2cc(-c3csc(NC(C)C)n3)nc3cc(OC)ccc23)C[C@H]1C(=O)O)C(=O)OCC

HCID86614778

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

To a solution of compound 74 (20 mg, 30 umol) in CH2Cl2 (2 mL) was added TFA (2 mL) and Et3SiH (10 uL, 63 umol). After 2 h the volatiles were evaporated and the product was used without any purification step. Compound 75: 18 mg, quant. as a white solid.

WORKUP

后处理

customAfter 2 h the volatiles were evaporated
customthe product was used without any purification step

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-85a039241d2f440e8e5fc5df0c8b6923
来源数据集: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07671032B2
来源说明: uspto-grants-2010_03

反应 SMILES

[CH2:1]([O:3][C:4]([C@@:6]1([NH:11][C:12]([C@@H:14]2[CH2:18][C@@H:17]([O:19][C:20]3[C:29]4[C:24](=[CH:25][C:26]([O:30][CH3:31])=[CH:27][CH:28]=4)[N:23]=[C:22]([C:32]4[N:33]=[C:34]([NH:37][CH:38]([CH3:40])[CH3:39])[S:35][CH:36]=4)[CH:21]=3)[CH2:16][C@H:15]2[C:41]([O:43]C(C)(C)C)=[O:42])=[O:13])[CH2:8][CH:7]1[CH:9]=[CH2:10])=[O:5])[CH3:2].C(O)(C(F)(F)F)=O.[SiH](CC)(CC)CC>C(Cl)Cl>[CH2:1]([O:3][C:4]([C@@:6]1([NH:11][C:12]([C@@H:14]2[CH2:18][C@@H:17]([O:19][C:20]3[C:29]4[C:24](=[CH:25][C:26]([O:30][CH3:31])=[CH:27][CH:28]=4)[N:23]=[C:22]([C:32]4[N:33]=[C:34]([NH:37][CH:38]([CH3:40])[CH3:39])[S:35][CH:36]=4)[CH:21]=3)[CH2:16][C@H:15]2[C:41]([OH:43])=[O:42])=[O:13])[CH2:8][CH:7]1[CH:9]=[CH2:10])=[O:5])[CH3:2]