Trifluoroacetic acid → HCID 57892960, compound

HRID 2242455Notes

Reaction equation

HRID 2242455 reaction equation
C(OC(=O)[NH:7][C@H:8]([CH2:13][N:14]=[N+:15]=[N-:16])[CH2:9][CH:10]([CH3:12])[CH3:11])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[N:14]([CH2:13][C@@H:8]([NH2:7])[CH2:9][CH:10]([CH3:12])[CH3:11])=[N+:15]=[N-:16]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 10037399HCID 10037399, compound

Product 1

HCID 57892960HCID 57892960, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

((1S)-1-Azidomethyl-3-methyl-butyl)-carbamic acid tert-butyl ester (9.64 g, 39.78 mmol) was treated with TFA (30 mL) in DCM (150 mL) for 3 hrs, the mixture was evaporated under reduced pressure and the residue was dissolved in ethyl acetate and washed with aqueous 1 M K2CO3, dried with Na2SO4 and concentrated to a yellow liquid (4.55 g, 80%).

Workup

  1. customthe mixture was evaporated under reduced pressure
  2. dissolutionthe residue was dissolved in ethyl acetate
  3. washwashed with aqueous 1 M K2CO3
  4. dry with materialdried with Na2SO4
  5. concentrationconcentrated to a yellow liquid (4.55 g, 80%)

Sources & evidence

ORD record
ord-d4e0c761f5374ce795cebe90f1728ff4
Source dataset
uspto-grants-2010_03
Patent number
US07671032B2

Reaction notes

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