Trifluoroacetic acid → HCID 86618168, compound

HRID 2242664Notes

Reaction equation

HRID 2242664 reaction equation
C(OC(=O)[NH:7][C@H:8]([C:31]([N:33]1[CH2:37][CH2:36][C@H:35]([F:38])[CH2:34]1)=[O:32])[C@H:9]([CH:11]1[CH2:16][CH2:15][CH:14]([NH:17][C:18](=[O:30])[C:19]2[CH:24]=[CH:23][C:22]([O:25][C:26]([F:29])([F:28])[F:27])=[CH:21][CH:20]=2)[CH2:13][CH2:12]1)[CH3:10])(C)(C)C.[F:40][C:41]([F:46])([F:45])[C:42]([OH:44])=[O:43]>ClCCl>[F:40][C:41]([F:46])([F:45])[C:42]([O-:44])=[O:43].[F:38][C@H:35]1[CH2:36][CH2:37][N:33]([C:31](=[O:32])[C@@H:8]([NH3+:7])[C@H:9]([CH:11]2[CH2:16][CH2:15][CH:14]([NH:17][C:18](=[O:30])[C:19]3[CH:20]=[CH:21][C:22]([O:25][C:26]([F:29])([F:27])[F:28])=[CH:23][CH:24]=3)[CH2:13][CH2:12]2)[CH3:10])[CH2:34]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 131727927HCID 131727927, compound

Product 1

HCID 86618168HCID 86618168, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of the material prepared in Step A (0.017 g, 0.036 mmol) in dichloromethane (3 mL) was added trifluoroacetic acid (1 mL). After 3 h at ambient temperature the reaction was concentrated in vacuo, affording the title compound as a white solid. LC/MS 406.3 (M+1).

Workup

  1. concentrationAfter 3 h at ambient temperature the reaction was concentrated in vacuo

Sources & evidence

ORD record
ord-65a7f579667f4414ac3012069349e2da
Source dataset
uspto-grants-2010_03
Patent number
US07671073B2

Reaction notes

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