反应详情

20 g of 37% hydrochloric acid (about 0.2 mol) and 20 ml of water are added, with stirring, to a solution of 40 g (0.158 mol) of 3-phenoxybenzylidene-isobutylamine in 40 ml of toluene, and the whole is refluxed for 15 minutes. The organic phase is separated; it is then washed neutral with 10% sodium hydrogen carbonate solution, and the toluene is removed by rotation in a slight water-jet vacuum. Distillation of the residue yields 29.7 g (0.15 mol) of 3-phenoxybenzaldehyde, corresponding to a yield of 94.9% of theory; b.p. 94° C./6 Pa; nD20 =1.5976.

1. temperaturethe whole is refluxed for 15 minutes
2. customThe organic phase is separated
3. washit is then washed neutral with 10% sodium hydrogen carbonate solution
4. customthe toluene is removed by rotation in a slight water-jet vacuum
5. distillationDistillation of the residue