Dimethylformamide dimethyl acetal → HCID 178433912, compound

HRID 2243217Notes

Reaction equation

HRID 2243217 reaction equation
CO[CH:3](OC)[N:4]([CH3:6])[CH3:5].[CH3:9][C:10]1[NH:14][C:13](=[O:15])[N:12]([C:16]2[CH:21]=[CH:20][C:19]([S:22][C:23]3[CH:24]=[C:25]([C:29]4([C:35]([NH2:37])=[O:36])[CH2:34][CH2:33][O:32][CH2:31][CH2:30]4)[CH:26]=[CH:27][CH:28]=3)=[CH:18][CH:17]=2)[N:11]=1>>[CH3:3][N:4](/[CH:6]=[N:37]/[C:35]([C:29]1([C:25]2[CH:26]=[CH:27][CH:28]=[C:23]([S:22][C:19]3[CH:18]=[CH:17][C:16]([N:12]4[C:13](=[O:15])[NH:14][C:10]([CH3:9])=[N:11]4)=[CH:21][CH:20]=3)[CH:24]=2)[CH2:30][CH2:31][O:32][CH2:33][CH2:34]1)=[O:36])[CH3:5]

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 135823070HCID 135823070, compound

Product 1

HCID 178433912HCID 178433912, compound

Procedure

N,N-Dimethylformamide dimethyl acetal (15 mL) was added to 4-(3-{[4-(3-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phenyl]thio}phenyl)tetrahydro-2H-pyran-4-carboxamide (2.0 g, 4.88 mmol) (example 10) and the reaction mixture was refluxed for about 2 hours. The solvent was evaporated under reduced pressure to obtain a light brown paste. Yield: 3.0 g.

Workup

  1. temperaturethe reaction mixture was refluxed for about 2 hours
  2. customThe solvent was evaporated under reduced pressure
  3. customto obtain a light brown paste

Sources & evidence

ORD record
ord-5ae6b8417ba548c0ae1ad858ded6d8d8
Source dataset
uspto-grants-2010_03
Patent number
US07674811B2

Reaction notes

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