反应详情

3-Methyl-4-nitrobenzyl chloride (8.57 g), 4-iodo-3-pentafluoroethyl-1H-pyrazole (16.00 g) and potassium carbonate (7.66 g) were stirred in DMF (70 ml) at 70° C. for 1 hour. After cooling, the reaction solution was poured into water and extracted with ethyl acetate. The organic phase was washed with water and saturated aqueous solution of sodium chloride. After drying the organic layer with sodium sulfate, the solvent was distilled off under the reduced pressure and the obtained residue was purified by silica gel column chromatography to obtain 4-iodo-1-(3-methyl-4-nitrobenzyl)-3-pentafluoroethyl-1H-pyrazole (4.60 g).

1. temperatureAfter cooling
2. extractionextracted with ethyl acetate
3. washThe organic phase was washed with water and saturated aqueous solution of sodium chloride
4. dry with materialAfter drying the organic layer with sodium sulfate
5. distillationthe solvent was distilled off under the reduced pressure
6. customthe obtained residue was purified by silica gel column chromatography