Potassium Carbonate → HCID 59210399, compound

HRID 2243277Notes

Reaction equation

HRID 2243277 reaction equation
[N+:1]([C:4]1[C:5]([CH3:11])=[CH:6][C:7]([OH:10])=[CH:8][CH:9]=1)([O-:3])=[O:2].CS([C:16]1[N:21]=[C:20]([C:22]([F:25])([F:24])[F:23])[CH:19]=[C:18]([C:26]([F:29])([F:28])[F:27])[N:17]=1)(=O)=O.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH3:11][C:5]1[CH:6]=[C:7]([CH:8]=[CH:9][C:4]=1[N+:1]([O-:3])=[O:2])[O:10][C:16]1[N:17]=[C:18]([C:26]([F:27])([F:28])[F:29])[CH:19]=[C:20]([C:22]([F:25])([F:23])[F:24])[N:21]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 174123-Methyl-4-nitrophenolHCID 19100537HCID 19100537, compound

Product 1

HCID 59210399HCID 59210399, compoundYield 55.8%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

4-Nitro-m-cresol (0.77 g), 2-methanesulfonyl-4,6-bistrifluoromethyl-pyrimidine (1.77 g) and potassium carbonate (1.04 g) were refluxed in acetonitrile (15 ml) for 5 hours. After finishing the reaction, the reaction mixture was poured into ice to separate out crystals. The obtained crystals were filtered and dried to obtain 2-(3-methyl-4-nitrophenoxy)-4,6-bistrifluoromethyl-pyrimidine (1.03 g).

Workup

  1. customthe reaction
  2. additionthe reaction mixture was poured into ice
  3. customto separate out crystals
  4. filtrationThe obtained crystals were filtered
  5. customdried

Sources & evidence

ORD record
ord-24fce7a72c7547d9ab239ce86e631cea
Source dataset
uspto-grants-2010_03
Patent number
US07674807B2

Reaction notes

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