Dichloromethane → HCID 68543319, compound

HRID 2243491Notes

Reaction equation

HRID 2243491 reaction equation
[CH3:1][O:2][C:3]([C:5]1[S:24][C:8]2[C:9]3[CH:10]=[CH:11][C:12]([NH:16]C(OC(C)(C)C)=O)=[CH:13][C:14]=3[S:15][C:7]=2[C:6]=1[O:25][CH2:26][C:27]([O:29][CH2:30][CH3:31])=[O:28])=[O:4].C(Cl)Cl.[C:35]([OH:41])([C:37]([F:40])([F:39])[F:38])=[O:36]>>[F:38][C:37]([F:40])([F:39])[C:35]([O-:41])=[O:36].[CH2:30]([O:29][C:27]([CH2:26][O:25][C:6]1[C:7]2[S:15][C:14]3[CH:13]=[C:12]([NH3+:16])[CH:11]=[CH:10][C:9]=3[C:8]=2[S:24][C:5]=1[C:3]([O:2][CH3:1])=[O:4])=[O:28])[CH3:31]

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 68543370HCID 68543370, compound

Product 1

HCID 68543319HCID 68543319, compound

Procedure

6-tert-Butoxycarbonylamino-1-ethoxycarbonylmethoxy-3,8-dithia-cyclopenta[a]indene-2-carboxylic acid methyl ester (684 mg, 1.5 mmol) was stirred in TFA (12 ml) and DCM (15 ml) for 3 hr. Removal of solvent by rotory evaporation yielded 729 mg (quantitative) of 1-ethoxycarbonylmethoxy-2-methoxycarbonyl-3,8-dithia-cyclopenta[a]inden-6-yl-ammonium trifluoroacetate.

Workup

  1. customRemoval of solvent
  2. customby rotory evaporation

Sources & evidence

ORD record
ord-206b45ba9efe4fe58ba873c53bdf210a
Source dataset
uspto-grants-2010_03
Patent number
US07674822B2

Reaction notes

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