2-Furancarbonyl chloride → HCID 68596857, compound

HRID 2243817Notes

Reaction equation

HRID 2243817 reaction equation
[N:1]12[CH2:9][CH2:8][CH:5]([CH2:6][CH2:7]1)[NH:4][CH2:3][CH2:2]2.[O:10]1[CH:14]=[CH:13][CH:12]=[C:11]1[C:15]([Cl:17])=[O:16].C(N(C(C)C)CC)(C)C>COCCOC>[ClH:17].[N:1]12[CH2:9][CH2:8][CH:5]([CH2:6][CH2:7]1)[N:4]([C:15]([C:11]1[O:10][CH:14]=[CH:13][CH:12]=1)=[O:16])[CH2:3][CH2:2]2

Participants

5

Reactant 3

HCID 682422-Furancarbonyl chlorideHCID 81531DiisopropylethylamineHCID 3984071,4-Diazabicyclo(3.2.2)nonane

Product 1

HCID 68596857HCID 68596857, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

A mixture of 1,4-Diaza-bicyclo[3.2.2]nonane (0.50 g; 4.0 mmol), 2-furoyl chloride (0.52 mg; 4.0 mmol), diisopropylethylamine (1.02 g; 7.9 mmol) and 1,2-dimethoxyethane (25 ml) was stirred at room-temperatue over night. The product precipitated as hydrochloric acid salt and was filtered and washed with 1,2-dimethoxyethane (5 ml). Yield 0.84 g (82%). Mp. 279-283° C.

Workup

  1. customThe product precipitated as hydrochloric acid salt
  2. filtrationwas filtered
  3. washwashed with 1,2-dimethoxyethane (5 ml)

Sources & evidence

ORD record
ord-0bc7aae5e15d44d0bfbff543c0389511
Source dataset
uspto-grants-2010_03
Patent number
US07678788B2

Reaction notes

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