Hydrazine hydrate (1:1) → 3-[1-(4-Fluoro-phenyl)-5-trifluoromethyl-1H-pyrazol-4-yl]-5,6,7,8,9,10-hexahydro-cycloocta[c]pyridazine

HRID 2243906Notes

Reaction equation

HRID 2243906 reaction equation
[C:1]1(=O)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][C:2]1=O.COP([CH2:17][C:18]([C:20]1[CH:21]=[N:22][N:23]([C:29]2[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=2)[C:24]=1[C:25]([F:28])([F:27])[F:26])=O)(=O)OC.O.[NH2:37][NH2:38]>>[F:35][C:32]1[CH:33]=[CH:34][C:29]([N:23]2[C:24]([C:25]([F:28])([F:27])[F:26])=[C:20]([C:18]3[N:38]=[N:37][C:2]4[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:1]=4[CH:17]=3)[CH:21]=[N:22]2)=[CH:30][CH:31]=1

Participants

4

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 5436981,2-CyclooctanedioneHCID 86609912{2-[1-(4-Fluoro-phenyl)-5-trifluoromethyl-1H-pyrazol-4-yl]-2-oxo-ethyl}-phosphonic acid dimethyl ester

Product 1

HCID 160635913-[1-(4-Fluoro-phenyl)-5-trifluoromethyl-1H-pyrazol-4-yl]-5,6,7,8,9,10-hexahydro-cycloocta[c]pyridazine

Procedure

off-white solid. MS (EI): 390.1 (M+). Prepared from cyclooctane-1,2-dione, {2-[1-(4-Fluoro-phenyl)-5-trifluoromethyl-1H-pyrazol-4-yl]-2-oxo-ethyl}-phosphonic acid dimethyl ester, hydrazine monohydrate.

Sources & evidence

ORD record
ord-2832930200994ddbba3ceea0f88f3461
Source dataset
uspto-grants-2010_03
Patent number
US07678795B2

Reaction notes

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