Hydrazine hydrate (1:1) → (1SR,8RS)-5-(5-Chloro-2-trifluoromethyl-phenyl)-3,4-diaza-tricyclo[6.2.1.02,7]undeca-2(7),3,5-triene

HRID 2243919Notes

Reaction equation

HRID 2243919 reaction equation
[CH:1]12[CH2:7][CH:4]([CH2:5][CH2:6]1)[C:3](=O)[C:2]2=O.COP([CH2:16][C:17]([C:19]1[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:20]=1[C:26]([F:29])([F:28])[F:27])=O)(=O)OC.O.[NH2:31][NH2:32]>>[Cl:25][C:23]1[CH:22]=[CH:21][C:20]([C:26]([F:29])([F:28])[F:27])=[C:19]([C:17]2[N:31]=[N:32][C:2]3[CH:1]4[CH2:7][CH:4]([C:3]=3[CH:16]=2)[CH2:5][CH2:6]4)[CH:24]=1

Participants

4

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 138696Bicyclo(2.2.1)heptane-2,3-dioneHCID 86609919[2-(5-Chloro-2-trifluoromethyl-phenyl)-2-oxo-ethyl]-phosphonic acid dimethyl ester

Product 1

HCID 16063664(1SR,8RS)-5-(5-Chloro-2-trifluoromethyl-phenyl)-3,4-diaza-tricyclo[6.2.1.02,7]undeca-2(7),3,5-triene

Procedure

yellow gum. MS (EI): 324.1 (M+). Prepared from bicyclo[2.2.1]heptane-2,3-dione, [2-(5-Chloro-2-trifluoromethyl-phenyl)-2-oxo-ethyl]-phosphonic acid dimethyl ester, hydrazine mono hydrate.

Sources & evidence

ORD record
ord-c257e67ceaab4538995fa6d002175d20
Source dataset
uspto-grants-2010_03
Patent number
US07678795B2

Reaction notes

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