Hydrazine hydrate (1:1) → (1S,8R)-5-(4-Chloro-2-methyl-phenyl)-1,11,11-trimethyl-3,4-diaza-tricyclo[6.2.1.02,7]undeca-2(7),3,5-triene

HRID 2243938노트

반응식

[CH3:1][C@@:2]12[C:8]([CH3:10])([CH3:9])[C@@H:5]([CH2:6][CH2:7]1)[C:4](=O)[C:3]2=O.COP([CH2:19][C:20]([C:22]1[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][C:23]=1[CH3:29])=O)(=O)OC.O.[NH2:31][NH2:32]>>[Cl:28][C:25]1[CH:26]=[CH:27][C:22]([C:20]2[N:31]=[N:32][C:3]3[C@:2]4([CH3:1])[C:8]([CH3:10])([CH3:9])[C@H:5]([C:4]=3[CH:19]=2)[CH2:6][CH2:7]4)=[C:23]([CH3:29])[CH:24]=1

참가 물질

반응물 3

HCID 24654Hydrazine hydrate (1:1)

HCID 1549179(+)-Camphorquinone

HCID 86609922[2-(4-Chloro-2-methyl-phenyl)-2-oxo-ethyl]-phosphonic acid dimethyl ester

생성물 1

HCID 67364461(1S,8R)-5-(4-Chloro-2-methyl-phenyl)-1,11,11-trimethyl-3,4-diaza-tricyclo[6.2.1.02,7]undeca-2(7),3,5-triene

실험 절차

yellow solid. MS (EI): 312.2 (M+). Prepared from (1S,4R)-1,7,7-trimethyl-bicyclo [2.2.1]heptane-2,3-dione, [2-(4-Chloro-2-methyl-phenyl)-2-oxo-ethyl]-phosphonic acid dimethyl ester, hydrazine monohydrate.

출처 및 근거

ORD 기록: ord-dc669a11d9884a819f51e38febee58c2
출처 데이터셋: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07678795B2

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