Hydrazine hydrate (1:1) → (1SR,8RS)-5-(1-tert-Butyl-5-trifluoromethyl-1H-pyrazol-4-yl)-3,4-diaza-tricyclo[6.2.1.02,7]undeca-2,4,6-triene

HRID 2243947Notes

Reaction equation

HRID 2243947 reaction equation
[CH:1]12[CH2:7][CH:4]([CH2:5][CH2:6]1)[C:3](=O)[C:2]2=O.COP([CH2:16][C:17]([C:19]1[CH:20]=[N:21][N:22]([C:28]([CH3:31])([CH3:30])[CH3:29])[C:23]=1[C:24]([F:27])([F:26])[F:25])=O)(=O)OC.O.[NH2:33][NH2:34]>>[C:28]([N:22]1[C:23]([C:24]([F:27])([F:26])[F:25])=[C:19]([C:17]2[CH:16]=[C:3]3[C:2]([CH:1]4[CH2:7][CH:4]3[CH2:5][CH2:6]4)=[N:34][N:33]=2)[CH:20]=[N:21]1)([CH3:31])([CH3:30])[CH3:29]

Participants

4

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 138696Bicyclo(2.2.1)heptane-2,3-dioneHCID 86609927[2-(1-tert-Butyl-5-trifluoromethyl-1H-pyrazol-4-yl)-2-oxo-ethyl]-phosphonic acid dimethyl ester

Product 1

HCID 67363888(1SR,8RS)-5-(1-tert-Butyl-5-trifluoromethyl-1H-pyrazol-4-yl)-3,4-diaza-tricyclo[6.2.1.02,7]undeca-2,4,6-triene

Procedure

light yellow crystalline solid. MS (ESI): 336.9 (MH+). Prepared from bicyclo[2.2.1]heptane-2,3-dione, [2-(1-tert-Butyl-5-trifluoromethyl-1H-pyrazol-4-yl)-2-oxo-ethyl]-phosphonic acid dimethyl ester, hydrazine monohydrate.

Sources & evidence

ORD record
ord-70ecbe4dea444671819addd732f7f159
Source dataset
uspto-grants-2010_03
Patent number
US07678795B2

Reaction notes

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