4-Aminophenol → HCID 57833527, compound

HRID 2244139Notes

Reaction equation

HRID 2244139 reaction equation
NC1C=C(C=CC=1)OC1C=CN=C(C(N)=O)C=1.[NH2:18][C:19]1[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][CH:20]=1.[F:26][C:27]1[CH:28]=[N:29][CH:30]=[C:31]([F:34])[C:32]=1F>>[F:26][C:27]1[CH:28]=[N:29][CH:30]=[C:31]([F:34])[C:32]=1[O:25][C:22]1[CH:23]=[CH:24][C:19]([NH2:18])=[CH:20][CH:21]=1

Participants

4

Reactant 3

HCID 4034-AminophenolHCID 161814653,4,5-TrifluoropyridineHCID 231372294-(3-Aminophenoxy)pyridine-2-carboxamide

Product 1

HCID 57833527HCID 57833527, compound

Procedure

{4-[(3,5-Difluoropyridin-4-yl) oxy]phenyl} amine (2E) was prepared by a method analogous to that described for 4-(3-aminophenoxy) pyridine-2-carboxamide (2C), starting from 4-aminophenol and 3, 4, 5-trifluoropyridine, MS ES: 223 (M+H)+, calcd 223, RT=0.50 min.

Sources & evidence

ORD record
ord-02ed669ff5cc432b9a2283d080a925dc
Source dataset
uspto-grants-2010_03
Patent number
US07678804B2

Reaction notes

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