反应详情

A mixture of 17.5 parts of 2-amino-1-phenylethanone hydrochloride, 16.5 parts of 1-isothiocyanato-4-methoxybenzene, 10 parts of sodium hydrogen carbonate and 200 parts of 2-propanol is stirred first for 30 minutes at room temperature and further for 2 hours at reflux temperature. The reaction mixture is poured onto 500 parts of water. The product is filtered off and stirred and refluxed for 1 hour with 240 parts of hydrochloric acid solution 10%. After cooling, the product is filtered off, washed with water and 2-propanol, and dried, yielding 25.3 parts (90%) of 1-(4-methoxyphenyl)-5-phenyl-1H-imidazole-2-thiol; mp. 167.4° C.

1. temperatureat reflux temperature
2. filtrationThe product is filtered off
3. stirringstirred
4. temperaturerefluxed for 1 hour with 240 parts of hydrochloric acid solution 10%
5. temperatureAfter cooling
6. filtrationthe product is filtered off
7. washwashed with water and 2-propanol
8. customdried