反应详情

To a solution of 2-bromopropionic acid tert-butyl ester (0.827 g, 3.95 mmol) in DMF (15 mL) is added [4-chloro-2-(5-chloro-2-hydroxy-benzyl)-phenoxy]-acetic acid benzyl ester (1.5 g, 3.60 mmol) and potassium carbonate (0.547 g, 3.95 mmol). The reaction mixture is stirred at RT overnight and the solvent is removed in vacuo. The crude product is dissolved in EtOAc (50 mL) and washed with water (50 mL) and brine (50 mL). The organic portion is dried (MgSO4) and concentrated in vacuo to yield a yellow oil which is dried in a vacuum oven for 2 hours to afford the titled product which is used in the next step without purification.

1. customthe solvent is removed in vacuo
2. dissolutionThe crude product is dissolved in EtOAc (50 mL)
3. washwashed with water (50 mL) and brine (50 mL)
4. dry with materialThe organic portion is dried (MgSO4)
5. concentrationconcentrated in vacuo
6. customto yield a yellow oil which
7. customis dried in a vacuum oven for 2 hours