Hydrochloric Acid → HCID 68554501, compound

HRID 2244496Notes

Reaction equation

HRID 2244496 reaction equation
Cl.[CH2:2]([CH2:5][NH2:6])[CH:3]=[CH2:4].[O:7]1[C:11]2([CH2:16][CH2:15][C:14](=O)[CH2:13][CH2:12]2)[O:10][CH2:9][CH2:8]1.[C-:18]#[N:19].[K+]>CO.O>[CH2:2]([CH2:5][NH:6][C:14]1([C:18]#[N:19])[CH2:15][CH2:16][C:11]2([O:10][CH2:9][CH2:8][O:7]2)[CH2:12][CH2:13]1)[CH:3]=[CH2:4]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 9032Potassium CyanideHCID 4437323-Buten-1-amineHCID 5674151,4-Dioxaspiro[4.5]decan-8-one

Product 1

HCID 68554501HCID 68554501, compoundYield 93.4%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A mixture of 9 ml water, 5.3 ml hydrochloric acid (32 per cent by weight), 8 ml methanol, 17.5 g allylmethylamine, 8.00 g 1,4-dioxaspiro[4.5]decan-8-one and 8.0 g potassium cyanide was stirred for 65 hours at room temperature. The yellowish-white suspension obtained was extracted four times with 25 ml diethyl ether each time, the combined extracts were dried over sodium sulfate, filtered and concentrated and the residue was largely freed from solvent residues in vacuo. 11.3 g 8-(allylmethylamino)-1,4-dioxaspiro[4.5]decane-8-carbonitrile were obtained as a pale brown liquid.

Workup

  1. customThe yellowish-white suspension obtained
  2. extractionwas extracted four times with 25 ml diethyl ether each time
  3. dry with materialthe combined extracts were dried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-a56641bc89c74891b7e4e61d9e1a4bda
Source dataset
uspto-grants-2010_03
Patent number
US07678834B2

Reaction notes

Loading…