反应详情

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine (1.00 g) was dissolved in 2-propanol (10 mL) at room temperature, and p-toluenesulfonic acid monohydrate (1.23 g) was added thereto at room temperature, followed by stirring at room temperature for 20 minutes. When the resultant mixture was cooled to 0° C., a salt was crystallized out of the mixture. After the resultant mixture was stirred at 0° C. for 2 hours, the precipitated salt was collected by filtration, and was washed with 2-propanol (2 mmol). The wet material was dried at room temperature under reduced pressure, to thereby give 1.91 g of the title compound.

1. customat room temperature
2. customa salt was crystallized out of the mixture
3. stirringAfter the resultant mixture was stirred at 0° C. for 2 hours
4. filtrationthe precipitated salt was collected by filtration
5. customThe wet material was dried at room temperature under reduced pressure