huagongshe.com
HRID2244633

反应详情

EQUATION

反应方程式

HRID 2244633 的结构方程式

REACTANTS

反应物

3
结构：COC(=O)CC(=O)OC
HCID7943

Dimethyl malonate

C5H8O4

结构：[H-].[Na+]
HCID24758

Sodium hydride

HNa

结构：N#Cc1ccc(F)c([N+](=O)[O-])c1
HCID2774654

4-fluoro-3-nitrobenzonitrile

C7H3FN2O2

PRODUCTS

生成物

1
结构：COC(=O)C(C(=O)OC)c1ccc(C#N)cc1[N+](=O)[O-]
HCID7210838

DIMETHYL 2-(4-CYANO-2-NITROPHENYL)MALONATE

C12H10N2O6

收率 39.4%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

To a solution of 4-fluoro-3-nitrobenzonitrile (300 mg) and dimethyl malonate (286 mg) in DMF was added 60% NaH at 0° C., followed by reaction at room temperature to obtain dimethyl (4-cyano-2-nitrophenyl)malonate (198 mg).

WORKUP

后处理

  1. customfollowed by reaction at room temperature