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HRID2244691

反应详情

EQUATION

反应方程式

HRID 2244691 的结构方程式

REACTANTS

反应物

2
结构：CN
HCID6329

Methylamine

CH5N

结构：O=C(N[C@H]1C[C@@H](C(=O)Nc2ccc(-n3ccccc3=O)cc2F)CC1=O)c1ccc(Cl)s1
HCID58826448

未命名化合物

PRODUCTS

生成物

1
结构：CNC1CC(C(=O)Nc2ccc(-n3ccccc3=O)cc2F)C[C@@H]1NC(=O)c1ccc(Cl)s1
HCID58826446

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

In analogy to example 24B 5-chloro-thiophene-2-carboxylic acid {(1S,4R)-4-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-2-oxo-cyclopentyl}-amide was reacted with methylamine (using a saturated solution in THF) to give 5-chloro-thiophene-2-carboxylic acid {(S)-4-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-2-methylamino-cyclopentyl}-amide. Crystalline white solid. MS 489.3 ([M+H]+).