Hydrochloric Acid → HCID 68682751, compound

HRID 2245311Notes

Reaction equation

HRID 2245311 reaction equation
[F:1][C:2]([F:19])([F:18])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)=[O:11])=[CH:6][CH:5]=1.[ClH:20]>C(O)C>[ClH:20].[F:18][C:2]([F:1])([F:19])[O:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)=[O:11])=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68681341HCID 68681341, compound

Product 1

HCID 68682751HCID 68682751, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 20.0 grams (0.075 mole) of 4-pyridyl 4-(trifluoromethoxy)phenyl ketone in 350 mL of ethanol was stirred as hydrogen chloride gas was bubbled through during a five minute period. Upon completion of addition, the reaction mixture was stirred for one hour, and then it was filtered to collect a solid. The solid was washed with three portions of diethyl ether, and dried in a vacuum oven, yielding about 22.0 grams of the subject compound. The NMR spectrum was consistent with the proposed structure.

Workup

  1. customwas bubbled through during a five minute period
  2. additionUpon completion of addition
  3. filtrationit was filtered
  4. customto collect a solid
  5. washThe solid was washed with three portions of diethyl ether
  6. customdried in a vacuum oven

Sources & evidence

ORD record
ord-8fe34076fa75497e95996cd165b7e016
Source dataset
uspto-grants-2010_03
Patent number
US07683070B2

Reaction notes

Loading…