Hydrochloric Acid → HCID 68681623, compound

HRID 2245315Notes

Reaction equation

HRID 2245315 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH:7]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[OH:8])=[CH:3][CH:2]=1.[ClH:19]>C(OCC)(=O)C>[ClH:19].[N:1]1[CH:2]=[CH:3][C:4]([CH:7]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:16])([F:17])[F:18])=[CH:11][CH:10]=2)[OH:8])=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11694508HCID 11694508, compound

Product 1

HCID 68681623HCID 68681623, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of 21.2 grams (0.070 mole) of 4-pyridyl[4-(trifluoromethyl)phenyl]methanol in 500 mL of ethyl acetate was stirred vigorously and anhydrous hydrogen chloride gas was slowly added during a 15 minute period, below the surface of the solution. The reaction mixture was then stirred for an additional 15 minutes, and a solid was collected by filtration. The solid was washed with ethyl acetate and dried, yielding 11.4 grams of the subject compound. The NMR spectrum was consistent with the proposed structure.

Workup

  1. filtrationa solid was collected by filtration
  2. washThe solid was washed with ethyl acetate
  3. customdried

Sources & evidence

ORD record
ord-100f368f1d82437cabd15e8b53886cef
Source dataset
uspto-grants-2010_03
Patent number
US07683070B2

Reaction notes

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