Dichloromethane → HCID 68687298, compound

HRID 2245345Notes

Reaction equation

HRID 2245345 reaction equation
[CH3:1][O:2][C:3]([C@H:5]1[C@@H:10]([NH2:11])[CH2:9][CH2:8][N:7]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:6]1)=[O:4].C(Cl)Cl.CCN([CH2:27][CH3:28])CC>>[CH3:1][O:2][C:3]([C@H:5]1[C@@H:10]([NH:11][C:3]([O:2][CH2:1][C:28]2[CH:27]=[CH:9][CH:10]=[CH:5][CH:6]=2)=[O:4])[CH2:9][CH2:8][N:7]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:6]1)=[O:4]

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 58745477HCID 58745477, compound

Product 1

HCID 68687298HCID 68687298, compound

Procedure

(3R,4S)-4-Amino-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester (540 mg, synthesized according to Duan, Jingwu et al, PCT Int. Appl. (2001), WO 2001070673 A2) and WO 2002002525) was dissolved in abs. DCM and NEt3 (0.39 ml) was added.

Sources & evidence

ORD record
ord-54a6637751ed42aeb3c2f4876f8ef097
Source dataset
uspto-grants-2010_03
Patent number
US07683079B2

Reaction notes

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