HRID2245516

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3939

Lithium hydroxide anhydrous

HLiO

HCID7369

Benzenesulfonyl chloride

C6H5ClO2S

结构：CCOC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(Cn2ccc3cc(N)ccc32)cc1

HCID68548160

未命名化合物

PRODUCTS

生成物

结构：O=C(N[C@@H](Cc1ccccc1)C(=O)O)c1ccc(Cn2ccc3cc(NS(=O)(=O)c4ccccc4)ccc32)cc1

HCID16113884

未命名化合物

PROCEDURE

实验过程

Treatment of ethyl N-{4-[(5-amino-1H-indol-1-yl)methyl]benzoyl}phenylalaninate with benzenesulfonyl chloride followed by LiOH hydrolysis as described in the procedure of Example 1 gave the title compound: MS (ESI) m/z 554; MS (ESI) m/z 552.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7ec04104ea414eee8125fd23f7c21450
来源数据集: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07683091B2
来源说明: uspto-grants-2010_03

反应 SMILES

[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:11][C:12]1[CH:33]=[CH:32][C:15]([C:16]([NH:18][C@H:19]([C:27]([O:29]CC)=[O:28])[CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[O:17])=[CH:14][CH:13]=1)[CH:6]=[CH:5]2.[C:34]1([S:40](Cl)(=[O:42])=[O:41])[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1.[Li+].[OH-]>>[C:34]1([S:40]([NH:1][C:2]2[CH:3]=[C:4]3[C:8](=[CH:9][CH:10]=2)[N:7]([CH2:11][C:12]2[CH:33]=[CH:32][C:15]([C:16]([NH:18][C@H:19]([C:27]([OH:29])=[O:28])[CH2:20][C:21]4[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=4)=[O:17])=[CH:14][CH:13]=2)[CH:6]=[CH:5]3)(=[O:42])=[O:41])[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1