HRID2245634

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID81531

Diisopropylethylamine

C8H19N

HCID22494327

未命名化合物

反应SMILES：CC(C)c1nnc(NS(=O)(=O)c2ccc(C3(CN)CCCCC3)cc2)s1.Cl

HCID68617696

未命名化合物

PRODUCTS

产物

反应SMILES：CCOc1cc(C(F)(F)F)ccc1C(=O)NCC1(c2ccc(S(=O)(=O)Nc3nnc(C(C)C)s3)cc2)CCCCC1

HCID16043214

未命名化合物

收率 94.6%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

Dimethylformamide

C3H7NO

PROCEDURE

实验过程

55 mg of 2-ethoxy-4-trifluoromethyl-benzoic acid (example 1g), 85 mg Totu and 100 mg N,N-diisopropylethylamine were dissolved in cold dimethylformamide. After 30 minutes 100 mg of 4-(1-aminomethyl-cyclohexyl)-N-(5-isopropyl-[1,3,4]thiadiazol-2-yl)-benzenesulfonamide hydrochloride were added and the mixture stirred over night. After evaporation of the solvent the residue was purified by chromatography on silica gel with the eluents dichloromethane:methanol=98:2 to obtain 134 mg of an oily product.

WORKUP

后处理

customAfter evaporation of the solvent the residue
customwas purified by chromatography on silica gel with the eluents dichloromethane

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-8df3379c60dc42dbbe8540dab1002e08
来源数据集: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US07683181B2
来源说明: uspto-grants-2010_03

反应SMILES

[CH2:1]([O:3][C:4]1[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:10]=[CH:9][C:5]=1[C:6]([OH:8])=O)[CH3:2].C(N(CC)C(C)C)(C)C.Cl.[NH2:27][CH2:28][C:29]1([C:35]2[CH:40]=[CH:39][C:38]([S:41]([NH:44][C:45]3[S:46][C:47]([CH:50]([CH3:52])[CH3:51])=[N:48][N:49]=3)(=[O:43])=[O:42])=[CH:37][CH:36]=2)[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]1>CN(C)C=O>[CH2:1]([O:3][C:4]1[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:10]=[CH:9][C:5]=1[C:6]([NH:27][CH2:28][C:29]1([C:35]2[CH:36]=[CH:37][C:38]([S:41](=[O:43])(=[O:42])[NH:44][C:45]3[S:46][C:47]([CH:50]([CH3:52])[CH3:51])=[N:48][N:49]=3)=[CH:39][CH:40]=2)[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34]1)=[O:8])[CH3:2]