反应详情

Sodium hydride (60% dispersion in mineral oil, 0.4 g) was added to a stirred suspension of 4-[4-(4-pyridyl)piperazin-1-yl]phenol (2.55 g) in DMF (25 ml) and the mixture stirred for 20 minutes at room temperature. Allyl chloride (0.756 g) was added dropwise and stirring continued for 20 hours. Ice-water (75 ml) was added and the mixture extracted three times with ethyl acetate. The combined extracts were washed with water and brine, dried (MgSO4) and evaporated. The residue was triturated with hexane and filtered to give 4-[4-(4-pyridyl)piperazin-1-yl]phenol allyl ether (2.5 g) as a solid;

1. stirringstirring
2. waitcontinued for 20 hours
3. extractionthe mixture extracted three times with ethyl acetate
4. washThe combined extracts were washed with water and brine
5. dry with materialdried (MgSO4)
6. customevaporated
7. customThe residue was triturated with hexane
8. filtrationfiltered