2-Amino-5-methylthiazole → HCID 54710606, compound

HRID 224600Notes

Reaction equation

HRID 224600 reaction equation
[CH3:1][N:2]1[C:7]([C:8]([O:10]C)=O)=[C:6]([OH:12])[C:5]2[CH:13]=[CH:14][C:15]([CH3:17])=[CH:16][C:4]=2[S:3]1(=[O:19])=[O:18].[NH2:20][C:21]1[S:22][C:23]([CH3:26])=[CH:24][N:25]=1>C1(C)C(C)=CC=CC=1>[CH3:1][N:2]1[C:7]([C:8]([NH:20][C:21]2[S:22][C:23]([CH3:26])=[CH:24][N:25]=2)=[O:10])=[C:6]([OH:12])[C:5]2[CH:13]=[CH:14][C:15]([CH3:17])=[CH:16][C:4]=2[S:3]1(=[O:19])=[O:18]

Participants

4

Reactant 2

HCID 3517702-Amino-5-methylthiazoleHCID 54703134HCID 54703134, compound

Product 1

HCID 54710606HCID 54710606, compoundYield 84.8%

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

2.83 gm (0.01 mol) of methyl 2,7-dimethyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylate-1,1-dioxide and 1.25 gm (0.011 mol) of 2-amino-5-methyl-thiazole were reacted in xylene analogous to Example 8, and 3.1 gm (84% of theory) of 2,7-dimethyl-4-hydroxy-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide were obtained

Sources & evidence

ORD record
ord-9b7aac0e9ff04d7599a5b5197e358698
Source dataset
uspto-grants-1980_11
Patent number
US04233299

Reaction notes

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