Hydroxylamine → 2-Fluoro-N'-hydroxy-4-(methanesulfonyl)benzene-1-carboximidamide

HRID 2246237Notes

Reaction equation

HRID 2246237 reaction equation
[F:1][C:2]1[CH:9]=[C:8]([S:10]([CH3:13])(=[O:12])=[O:11])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[NH2:14][OH:15]>C(O)C>[F:1][C:2]1[CH:9]=[C:8]([S:10]([CH3:13])(=[O:12])=[O:11])[CH:7]=[CH:6][C:3]=1[C:4](=[N:14][OH:15])[NH2:5]

Participants

4

Reactant 2

HCID 787HydroxylamineHCID 223464252-Fluoro-4-(methylsulfonyl)benzonitrile

Product 1

HCID 714136082-Fluoro-N'-hydroxy-4-(methanesulfonyl)benzene-1-carboximidamide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

To a stirred solution of the product from Step E (0.29 g, 0.144 mmol) in ethanol (15 mL) was added hydroxylamine (50% in water, 3.0 mL). The reaction was heated at 90° C. for 3 h. The reaction was then concentrated to give the desired product.

Workup

  1. concentrationThe reaction was then concentrated

Sources & evidence

ORD record
ord-c72f38cdac23496b9ee55ba9e6cbc827
Source dataset
uspto-grants-2010_03
Patent number
US07687492B2

Reaction notes

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