Imidazole → HCID 25260769, compound

HRID 2246535Notes

Reaction equation

HRID 2246535 reaction equation
Br[CH2:2][CH2:3][CH2:4][Si:5]([CH3:35])([CH3:34])[CH2:6][CH2:7][C:8]1[C:20]2[CH2:19][N:18]3[C:13](=[CH:14][C:15]4[C@:25]([CH2:27][CH3:28])([OH:26])[C:24](=[O:29])[O:23][CH2:22][C:16]=4[C:17]3=[O:21])[C:12]=2[N:11]=[C:10]2[CH:30]=[CH:31][CH:32]=[CH:33][C:9]=12.[NH:36]1[CH:40]=[CH:39][N:38]=[CH:37]1>CN(C)C=O>[CH2:27]([C@:25]1([OH:26])[C:15]2[CH:14]=[C:13]3[N:18]([C:17](=[O:21])[C:16]=2[CH2:22][O:23][C:24]1=[O:29])[CH2:19][C:20]1[C:8]([CH2:7][CH2:6][Si:5]([CH2:4][CH2:3][CH2:2][N:36]2[CH:40]=[CH:39][N:38]=[CH:37]2)([CH3:34])[CH3:35])=[C:9]2[CH:33]=[CH:32][CH:31]=[CH:30][C:10]2=[N:11][C:12]3=1)[CH3:28]

Participants

4

Reactant 2

HCID 795ImidazoleHCID 25260614HCID 25260614, compound

Product 1

HCID 25260769HCID 25260769, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of Compound 11 (60 mg) and imidazole (37 mg) in dry N,N-dimethylformamide (1 mL) was heated at 70° C. for 16 hours under argon. The N,N-dimethylformamide was removed from the reaction mixture under vacuum and the residue was directly eluted on a silica gel column using 3% ethanol in dichloromethane to obtain the required product in 77% yield (45 mg).

Workup

  1. customThe N,N-dimethylformamide was removed from the reaction mixture under vacuum
  2. washthe residue was directly eluted on a silica gel column

Sources & evidence

ORD record
ord-f167b8856bde454f93929356a42c7762
Source dataset
uspto-grants-2010_03
Patent number
US07687496B2

Reaction notes

Loading…