Trimethyl phosphite → HCID 25262631, compound

HRID 2246539Notes

Reaction equation

HRID 2246539 reaction equation
I[CH2:2][CH2:3][CH2:4][Si:5]([CH3:35])([CH3:34])[CH2:6][CH2:7][C:8]1[C:20]2[CH2:19][N:18]3[C:13](=[CH:14][C:15]4[C@:25]([CH2:27][CH3:28])([OH:26])[C:24](=[O:29])[O:23][CH2:22][C:16]=4[C:17]3=[O:21])[C:12]=2[N:11]=[C:10]2[CH:30]=[CH:31][CH:32]=[CH:33][C:9]=12.[P:36]([O:41]C)([O:39][CH3:40])[O:37][CH3:38]>>[CH3:38][O:37][P:36]([CH2:2][CH2:3][CH2:4][Si:5]([CH2:6][CH2:7][C:8]1[C:20]2[CH2:19][N:18]3[C:13](=[CH:14][C:15]4[C@:25]([CH2:27][CH3:28])([OH:26])[C:24](=[O:29])[O:23][CH2:22][C:16]=4[C:17]3=[O:21])[C:12]=2[N:11]=[C:10]2[CH:30]=[CH:31][CH:32]=[CH:33][C:9]=12)([CH3:35])[CH3:34])(=[O:41])[O:39][CH3:40]

Participants

3

Reactant 2

HCID 8472Trimethyl phosphiteHCID 25260767HCID 25260767, compound

Product 1

HCID 25262631HCID 25262631, compoundYield 76%

Procedure

A solution of Compound 12 (60 mg) in trimethyl phosphite (1 mL) was heated under argon at 80° C. for 10 hours. Trimethyl phosphite was removed from the reaction mixture under vacuum and the residue was eluted on a silica gel using 4% ethanol in dichloromethane to obtain the required product in 76% yield (44 mg).

Workup

  1. customTrimethyl phosphite was removed from the reaction mixture under vacuum
  2. washthe residue was eluted on a silica gel using 4% ethanol in dichloromethane

Sources & evidence

ORD record
ord-19c5f7ee46734e3fba3eb025d706bff5
Source dataset
uspto-grants-2010_03
Patent number
US07687496B2

Reaction notes

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