4-Chlorobenzoyl chloride → HCID 23331741, compound

HRID 224662Notes

Reaction equation

HRID 224662 reaction equation
[C:1]([O:4][CH2:5][CH2:6][N:7]1[C:11]([CH3:12])=[CH:10][CH:9]=[C:8]1[CH3:13])(=[O:3])[CH3:2].[Cl:14][C:15]1[CH:23]=[CH:22][C:18]([C:19](Cl)=[O:20])=[CH:17][CH:16]=1.[Cl-].[Al+3].[Cl-].[Cl-]>ClCCCl>[C:1]([O:4][CH2:5][CH2:6][N:7]1[C:8]([CH3:13])=[CH:9][C:10]([C:19](=[O:20])[C:18]2[CH:22]=[CH:23][C:15]([Cl:14])=[CH:16][CH:17]=2)=[C:11]1[CH3:12])(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 85014-Chlorobenzoyl chlorideHCID 6451240Aluminum(III) ChlorideHCID 23331782HCID 23331782, compound

Product 1

HCID 23331741HCID 23331741, compoundYield 34%

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

In 1,2-dichloroethane, 2-(2,5-dimethylpyrrol-1-yl)ethyl acetate was reacted with p-chlorobenzoyl chloride in the presence of aluminum chloride at room temperature for 18 hours to afford compound (340) in a yield of 34.0%.

Sources & evidence

ORD record
ord-ba80f5dd979d4d7b85a92d166cb44575
Source dataset
uspto-grants-1980_11
Patent number
US04233309

Reaction notes

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