HRID2246631

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID24758

Sodium hydride

HNa

HCID2801562

未命名化合物

结构：Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc2[nH]ncc2c1

HCID10403067

N-Cyclopropyl-3-fluoro-5-(1H-indazol-5-yl)-4-methylbenzamide

C18H16FN3O

2 次

PRODUCTS

生成物

结构：Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc2c(cnn2CC2CN(Cc3ccccc3)CCO2)c1

HCID11249024

未命名化合物

收率 4.7%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

The procedure for Example 1 was followed using sodium hydride (60% in mineral oil, 19.4 mg), N-cyclopropyl-3-fluoro-5-(1H-indazol-5-yl)-4-methylbenzamide (Intermediate 3, 100 mg) and 4-benzyl-2-(chloromethyl)morpholine (87.6 mg) in DMF (5 ml) to give the crude product (70 mg) A portion (10 mg) was subjected to preparative HPLC to give the title compound as a white solid (7.6 mg).

WORKUP

后处理

customto give the crude product (70 mg) A portion (10 mg)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-744be17320794f87b140e6a86051119c
来源数据集: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07687532B2
来源说明: uspto-grants-2010_03

反应 SMILES

[H-].[Na+].[CH:3]1([NH:6][C:7](=[O:25])[C:8]2[CH:13]=[C:12]([C:14]3[CH:15]=[C:16]4[C:20](=[CH:21][CH:22]=3)[NH:19][N:18]=[CH:17]4)[C:11]([CH3:23])=[C:10]([F:24])[CH:9]=2)[CH2:5][CH2:4]1.[CH2:26]([N:33]1[CH2:38][CH2:37][O:36][CH:35]([CH2:39]Cl)[CH2:34]1)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>CN(C=O)C>[CH2:26]([N:33]1[CH2:38][CH2:37][O:36][CH:35]([CH2:39][N:19]2[C:20]3[C:16](=[CH:15][C:14]([C:12]4[CH:13]=[C:8]([CH:9]=[C:10]([F:24])[C:11]=4[CH3:23])[C:7]([NH:6][CH:3]4[CH2:4][CH2:5]4)=[O:25])=[CH:22][CH:21]=3)[CH:17]=[N:18]2)[CH2:34]1)[C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1