Methylamine → HCID 16067642, compound

HRID 2246746Notes

Reaction equation

HRID 2246746 reaction equation
Cl.[CH:2]1([N:5]2[C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=3[N:7]([C@H:14]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:15][CH2:16][NH:17][CH3:18])[C:6]2=[O:25])[CH2:4][CH2:3]1.C1(N2C3C=CC=CC=3N([C@H](C3C=CC=CC=3)CCCl)C2=O)CC1.CN>>[CH:2]1([N:5]2[C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=3[N:7]([C@H:14]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:15][CH2:16][NH:17][CH3:18])[C:6]2=[O:25])[CH2:3][CH2:4]1

Participants

4

Reactant 3

HCID 6329MethylamineHCID 68523673HCID 68523673, compoundHCID 68525657HCID 68525657, compound

Product 1

HCID 16067642HCID 16067642, compound

Procedure

In an analogous manner to Example 14, step 3 1-cyclopropyl-3-[(1S)-3-(methylamino)-1-phenylpropyl]-1,3-dihydro-2H-benzimidazol-2-one HCl salt as a yellow amorphous solid was prepared from 1-cyclopropyl-3-[(1S)-3-(chloro)-1-phenylpropyl]-1,3-dihydro-2H-benzimidazol-2-one and methylamine. MS (ESI) m/z 322. HRMS: calculated for C20H23N3O+H+, 322.19139; found (ESI, [M+H]+), 322.192.

Sources & evidence

ORD record
ord-e5bc40e7a5454fb7a64b601c7f5e6bb9
Source dataset
uspto-grants-2010_03
Patent number
US07687529B2

Reaction notes

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