Potassium Carbonate → 4-(4-Nitrophenyl)-morpholin-3-ON

HRID 2246806Notes

Reaction equation

HRID 2246806 reaction equation
Cl[CH2:2][CH2:3][O:4][CH2:5][C:6]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=1)=[O:7].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[N+:15]([C:12]1[CH:13]=[CH:14][C:9]([N:8]2[CH2:2][CH2:3][O:4][CH2:5][C:6]2=[O:7])=[CH:10][CH:11]=1)([O-:17])=[O:16]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 116158572-(2-chloroethoxy)-N-(4-nitrophenyl)acetamide

Product 1

HCID 114473754-(4-Nitrophenyl)-morpholin-3-ON

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

1.3 1 kg of “A1” is dissolved in 5 liters of acetonitrile at room temperature, 835 g of potassium carbonate are added, and the mixture is stirred at this temperature for 18 hours. The mixture is warmed to 50° and worked up analogously to Example 6, giving 4-(4-nitrophenyl)-3-oxomorpholine (“A2”), m.p. 150-152°.

Workup

  1. temperatureThe mixture is warmed to 50°

Sources & evidence

ORD record
ord-b7623c50dd47441493dfdfc3dc886d17
Source dataset
uspto-grants-2010_03
Patent number
US07687624B2

Reaction notes

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