Dichloromethane → HCID 11281969, compound

HRID 2247057Notes

Reaction equation

HRID 2247057 reaction equation
[C:1]([CH:6]=[C:7]1[CH2:12][CH2:11][N:10]([C:13]2[CH:18]=[CH:17][C:16]([N:19]3[CH2:23][C@H:22]([CH2:24][NH:25][C:26](=[O:28])[CH3:27])[O:21][C:20]3=[O:29])=[CH:15][C:14]=2[F:30])[CH2:9][CH2:8]1)([O:3]CC)=[O:2].ClC1C=CC=C([C:38](OO)=[O:39])C=1.Cl[CH2:43]Cl>>[C:1]([CH:6]1[C:7]2([CH2:8][CH2:9][N:10]([C:13]3[CH:18]=[CH:17][C:16]([N:19]4[CH2:23][C@H:22]([CH2:24][NH:25][C:26](=[O:28])[CH3:27])[O:21][C:20]4=[O:29])=[CH:15][C:14]=3[F:30])[CH2:11][CH2:12]2)[CH2:43]1)([O:3][O:39][CH3:38])=[O:2]

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 70297m-Chloroperbenzoic acidHCID 10364769HCID 10364769, compound

Product 1

HCID 11281969HCID 11281969, compoundYield 37%

Procedure

The title compound was prepared by reacting (S)-N-[3-{4-[4-carboethoxymethylidenepiperidin-1-yl]-3-fluorophenyl}-2-oxo-1,3-oxazolidin-5-ylmethyl]-acetamide (0.3 mmol) and m-chloroperbenzoic acid (0.31 mmol) in dichloromethane at a temperature 0° C. for 14 hours in 37% yield.

Workup

  1. customat a temperature 0° C.
  2. customfor 14 hours

Sources & evidence

ORD record
ord-8438ccf650fc42d0b474bb83fe2c7591
Source dataset
uspto-grants-2010_03
Patent number
US07687627B2

Reaction notes

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