Ethylene Glycol → HCID 60133537, compound

HRID 2247066Notes

Reaction equation

HRID 2247066 reaction equation
[O:1]=[C:2]1[CH2:7][CH2:6][N:5]([C:8]2[C:13]([F:14])=[CH:12][C:11]([N:15]3[CH2:19][C@H:18]([CH2:20][NH:21][C:22](=[O:24])[CH3:23])[O:17][C:16]3=[O:25])=[CH:10][C:9]=2[F:26])[CH2:4][CH2:3]1.[CH2:27](O)[CH2:28][OH:29].C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[O:29]1[C:2]2([CH2:3][CH2:4][N:5]([C:8]3[C:13]([F:14])=[CH:12][C:11]([N:15]4[CH2:19][C@H:18]([CH2:20][NH:21][C:22](=[O:24])[CH3:23])[O:17][C:16]4=[O:25])=[CH:10][C:9]=3[F:26])[CH2:6][CH2:7]2)[O:1][CH2:27][CH2:28]1

Participants

5

Reactant 3

HCID 174Ethylene GlycolHCID 6101p-Toluenesulfonic acidHCID 53773721HCID 53773721, compound

Product 1

HCID 60133537HCID 60133537, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The compound was prepared by reacting (S)-N-{3-[4-(4-oxo-piperidin-1-yl)-3,5-difluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide (0.5 mmol), ethylene glycol (0.5 mmol), p-toluene sulfonic acid (0.3 mmol) in toluene and by purifying on silica gel column chromatography to provide title compound in 77% yield.

Workup

  1. customThe compound was prepared
  2. customby purifying on silica gel column chromatography

Sources & evidence

ORD record
ord-5cf551c26d7e427b9c04bc848cb1681f
Source dataset
uspto-grants-2010_03
Patent number
US07687627B2

Reaction notes

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