Ethyl isocyanate → HCID 85861689, compound

HRID 2247344Notes

Reaction equation

HRID 2247344 reaction equation
[CH2:1]([N:3]=[C:4]=[O:5])[CH3:2].[CH3:6][S:7]([C:10]1[CH:15]=[CH:14][C:13]([C:16]2[S:20][C:19]([NH2:21])=[N:18][C:17]=2[CH3:22])=[CH:12][CH:11]=1)(=[O:9])=[O:8]>CN(C)C=O>[CH2:1]([NH:3][C:4]([NH:21][C:19]1[S:20][C:16]([C:13]2[CH:12]=[CH:11][C:10]([S:7]([CH3:6])(=[O:9])=[O:8])=[CH:15][CH:14]=2)=[C:17]([CH3:22])[N:18]=1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 8022Ethyl isocyanateHCID 57473751HCID 57473751, compound

Product 1

HCID 85861689HCID 85861689, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
85 °C

Procedure

Ethyl isocyanate (0.09 ml, 1.1 mmol) is added to a stirred solution of 5-(4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-ylamine (Example 58) (0.10 g, 0.37 mmol) in dimethylformamide (1.0 ml). The mixture is heated at 85° C. for 90 minutes followed by removal of the solvent. The residue is crystallised from ethyl acetate—methanol to afford the title compound. MH+ 340.0.

Workup

  1. customfollowed by removal of the solvent
  2. customThe residue is crystallised from ethyl acetate—methanol

Sources & evidence

ORD record
ord-4bab28bd0445411a991df8034476c8f7
Source dataset
uspto-grants-2010_03
Patent number
US07687637B2

Reaction notes

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