Ethyl isocyanate → HCID 86598413, compound

HRID 2247354Notes

Reaction equation

HRID 2247354 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:12]2[S:16][C:15]([NH2:17])=[N:14][C:13]=2[CH3:18])[CH:5]=[CH:6][C:7]=1[S:8]([CH3:11])(=[O:10])=[O:9].[CH2:19]([N:21]=[C:22]=[O:23])[CH3:20]>CN(C=O)C>[CH2:19]([NH:21][C:22]([NH:17][C:15]1[S:16][C:12]([C:4]2[CH:5]=[CH:6][C:7]([S:8]([CH3:11])(=[O:9])=[O:10])=[C:2]([F:1])[CH:3]=2)=[C:13]([CH3:18])[N:14]=1)=[O:23])[CH3:20]

Participants

4

Reactant 2

HCID 8022Ethyl isocyanateHCID 573512775-(3-Fluoro-4-(methylsulfonyl)phenyl)-4-methylthiazol-2-amine

Product 1

HCID 86598413HCID 86598413, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
85 °C

Procedure

A mixture of 5-(3-fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-ylamine (0.40 g, 1.4 mmol) and ethyl isocyanate (0.121 ml, 1.5 mmol) in dry DMF (3 ml) is heated at 85° C. for 1 hour. The solvent is removed and the product is purified by chromatography on silica eluting with hexane—ethyl acetate (1:1) to give the title compound.

Workup

  1. customThe solvent is removed
  2. customthe product is purified by chromatography on silica eluting with hexane—ethyl acetate (1:1)

Sources & evidence

ORD record
ord-6a1822623503469bb238b3f34bdb9e75
Source dataset
uspto-grants-2010_03
Patent number
US07687637B2

Reaction notes

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