Ethanolamine → HCID 85861706, compound

HRID 2247355Notes

Reaction equation

HRID 2247355 reaction equation
[C:1]([NH:4][C:5]1[S:6][C:7]([C:11]2[CH:19]=[CH:18][C:14]([C:15]([OH:17])=O)=[CH:13][CH:12]=2)=[C:8]([CH3:10])[N:9]=1)(=[O:3])[CH3:2].CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C.[CH2:53]([CH2:55][NH2:56])[OH:54]>CN(C=O)C>[C:1]([NH:4][C:5]1[S:6][C:7]([C:11]2[CH:12]=[CH:13][C:14]([C:15]([NH:56][CH2:55][CH2:53][OH:54])=[O:17])=[CH:18][CH:19]=2)=[C:8]([CH3:10])[N:9]=1)(=[O:3])[CH3:2]

Participants

6

Reactant 4

HCID 700EthanolamineHCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 82161561HCID 82161561, compound

Product 1

HCID 85861706HCID 85861706, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To 4-(2-acetylamino-4-methyl-thiazol-5-yl)-benzoic acid (Example 74b) (0.1 g, 0.36 mmol) in DMF (1 ml) is added HATU (0.14 g, 0.36 mmol) followed by DIPEA (0.07 ml, 0.36 mmol) and ethanolamine (0.022 ml, 0.36 mmol). After 5 hours, the reaction mixture is filtered and the precipitated product is washed with ethanol and dried under vacuum to give the titled compound.

Workup

  1. filtrationthe reaction mixture is filtered
  2. washthe precipitated product is washed with ethanol
  3. customdried under vacuum

Sources & evidence

ORD record
ord-4457dcabbef54dddb645d77bf18691c2
Source dataset
uspto-grants-2010_03
Patent number
US07687637B2

Reaction notes

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